|
KMID : 1145520180040010026
|
|
Journal of Radiopharmaceuticals and Molecular Probes
2018 Volume.4 No. 1 p.26 ~ p.31
|
|
|
Molecular imaging of atherosclerosis using reporter gene system
|
|
Yoo Ran-Ji
Lee Kyo-Chul
Kang Joo-Hyun
Lee Yong-Jin
|
|
|
Abstract
|
|
|
|
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using 99mTc-SPECT. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.
|
|
|
KEYWORD
|
|
|
Atherosclerosis, Click chemistry, Macrophage, Reporter gene, SPECT imaging, PET imaging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|